We use mass spectrometry-based analyses to study cell signaling. We have focused on the analyses of kinases, key regulatory nodes in many cellular signaling pathways. To enhance our ability to study these kinases, we synthesize our own affinity reagents that use immobilized non-selective kinase inhibitors to selectively enrich ~70% of the kinases known in the human genome. This allows us to compare kinase expression and activity between different cellular states, using quantitative proteomics approaches like SILAC.
View our Selected publications for a curated list of work from the lab.